Flow eld around a hypersonic re-entry conguration is computed using the Detached eddy simulation methodology at two dierent Reynolds numbers. The lower Reynolds number condition corresponds to the 35 km altitude trajectory point of the Fire II vehicle. The near wake is found to be transitional these free-stream conditions, and the computations highlight the limitations of DES in low Re ows. The higher Re computations are performed at a free-stream density that is higher than the earlier value by a factor of 10. The timeaveraged ow solutions are compared to study the eect of Reynolds number on the DES methodology and predictions. The analysis brings out interesting parallels between the two owelds. The dierences between DES and RANS predictions at the two Reynolds number are also discussed.